Na priredbi se održavaju dvije borbe za naslov prvaka. TJ Dillashaw brani pojas u bantamu u revanšu protiv Codyja Garbrandta, a Demetrious Johnson također u revanšu protiv Henryja Cejuda.
UFC 227:
T.J. Dillashaw (61.2) vs. Cody Garbrandt (61.1)
Demetrious Johnson (56.7) vs. Henry Cejudo (56.5)
Thiago Santos (84.1) vs. Kevin Holland (83.8)
Polyana Viana (52.2) vs. JJ Aldrich (52.3)
Cub Swanson (65.9) vs. Renato Moicano (66.2)
Pedro Munhoz (61.2) vs. Brett Johns (61.3)
Ricky Simon (61.3) vs. Montel Jackson (61.7)
Ricardo Ramos (61.5) vs. Kyung Ho Kang (61.7)
Matt Sayles (66.1) vs. Sheymon Moraes (66.2)
Jose Torres (125) vs. Alex Perez (126)
Danielle Taylor (52.2) vs. Zhang Weili (52.4)
Marlon Vera (61.4) vs. Wuliji Buren (61.4)